A SUCCESSFUL MURINE MODEL FOR CONTACT SENSITIZATION TO A SESQUITERPENE-ALPHA-METHYLENE-GAMMA-BUTYROLACTONE - SENSITIZATION TO ALANTOLACTONE IN 4 STRAINS OF MICE

被引：4

作者：

FRAGINALS, R

BLASI, NA

LEPOITTEVIN, JP

BENEZRA, C

机构：

[1] UNIV CADIZ,FAC MED,CADIZ,SPAIN

[2] UNIV STRASBOURG 1,INST HEMATOL & IMMUNOL,F-67070 STRASBOURG,FRANCE

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1991年 / 97卷 / 03期

关键词：

D O I：

10.1111/1523-1747.ep12481500

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Induction of allergic contact hypersensitivity to a sesquiterpene lactone, alantolactone, was studied in four strains of mice: C3H/He, DBA/2, Balb/b, and Balb/c. The last three were successfully sensitized. A significant dose/response was demonstrated in these species, as well as an experimental "overload effect" in Balb/c and Balb/b strains. Histologic studies confirmed the allergic nature of the reaction. From the overall results, alantolactone can be considered a moderate sensitizer in mouse as well as in guinea pig. This study shows that the murine model can be used for experimental contact sensitization with moderate allergens, without the use of Freund's adjuvant for induction.

引用

页码：473 / 477

页数：5

共 21 条

[1] NATURAL AND SYNTHETIC ALLERGY-PRODUCING LACTONES
BENEZRA, C
SCHLEWER, G
STAMPF, JL
[J]. REVUE FRANCAISE D ALLERGOLOGIE ET D IMMUNOLOGIE CLINIQUE, 1978, 18 (01): : 31 - 33
[2] BENEZRA C, 1985, PLANT CONTACT DERMAT
[3] CLAMAN HN, 1966, IMMUNOL REV, V50, P106
[4] GENETIC-CONTROL OF CONTACT SENSITIVITY TO OXAZOLONE IN INBRED, H-2 CONGENIC AND INTRA-H-2 RECOMBINANT STRAINS OF MICE
FACHET, J
ANDO, I
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1977, 7 (04) : 223 - 226
[5] SENSITIZING CAPACITY OF 3 METHYL ALKANESULPHONATES - A MURINE INVIVO AND INVITRO MODEL OF ALLERGIC CONTACT-DERMATITIS
FRAGINALS, R
LEPOITTEVIN, JP
BENEZRA, C
[J]. ARCHIVES OF DERMATOLOGICAL RESEARCH, 1990, 282 (07) : 455 - 458
[6] DEVELOPMENT AND VALIDATION OF AN ALTERNATIVE DERMAL SENSITIZATION TEST - THE MOUSE EAR SWELLING TEST (MEST)
GAD, SC
DUNN, BJ
DOBBS, DW
REILLY, C
WALSH, RD
[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1986, 84 (01) : 93 - 114
[7] GREENE MI, 1984, FUNDAMENTAL IMMUNOLO, P685
[8] CHRYSANTHEMUM ALLERGY .3. IDENTIFICATION OF ALLERGENS
HAUSEN, BM
SCHULZ, KH
[J]. ARCHIVES OF DERMATOLOGICAL RESEARCH, 1976, 255 (02) : 111 - 121
[9] GENETIC-CONTROL OF NICKEL SULFATE DELAYED-TYPE HYPERSENSITIVITY
ISHII, N
ISHII, H
ONO, H
HORIUCHI, Y
NAKAJIMA, H
AOKI, I
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 94 (05) : 673 - 676
[10] ASPECTS OF THE IMMUNE-RESPONSE TO CONTACT ALLERGENS - OPPORTUNITIES FOR THE DEVELOPMENT AND MODIFICATION OF PREDICTIVE TEST METHODS
KIMBER, I
[J]. FOOD AND CHEMICAL TOXICOLOGY, 1989, 27 (11) : 755 - 762

← 1 2 3 →