FLUORIDE STIMULATES [H-3] THYMIDINE INCORPORATION AND ALKALINE-PHOSPHATASE PRODUCTION BY HUMAN OSTEOBLASTS

被引：50

作者：

KHOKHER, MA ^{[1
]}

DANDONA, P ^{[1
]}

机构：

[1] ROYAL FREE HOSP,SCH MED,DEPT CHEM PATHOL & HUMAN METAB,METAB UNIT,POND ST,LONDON NW3 2QG,ENGLAND

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1990年 / 39卷 / 11期

关键词：

D O I：

10.1016/0026-0495(90)90081-M

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of sodium fluoride on alkaline phosphatase (ALP) release and [3H]thymidine uptake by human osteoblasts in culture was investigated. Sodium fluoride stimulated both ALP release and [3H]thymidine uptake at concentrations of sodium fluoride greater than 250 μmol/L. This stimulation was similar in magnitude to that induced by 1,25-dihydroxycholecalciferol. The fluoride-induced increase in ALP was inhibited by verapamil, a calcium channel blocker. We conclude that sodium fluoride stimulates osteoblasts to proliferate and to release ALP. This stimulation by fluoride is dependent on calcium influx. Fluoride-induced stimulation of human osteoblasts may be relevant to its effect in enhancing bone formation in patients with osteoporosis. © 1990.

引用

页码：1118 / 1121

页数：4

共 12 条

[11] CLINICAL-EVALUATION OF BONE TURNOVER BY SERUM OSTEOCALCIN MEASUREMENTS IN A HOSPITAL SETTING [J].