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INTERMOLECULAR COOPERATIVITY - A CLUE TO WHY MICE HAVE IGG3

被引：72
作者：
GREENSPAN, NS
COOPER, LJN
机构：
[1] Neil Greenspan and Laurence Cooper are, the Institute of Pathology, Case Western Reserve University, Cleveland
来源：
IMMUNOLOGY TODAY | 1992年 / 13卷 / 05期
关键词：
D O I：
10.1016/0167-5699(92)90120-V
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mouse IgG3 subclass antibodies predominate in humoral responses to bacterial polysaccharide antigens. The reasons for this isotype restriction are not fully understood. Here, Neil Greenspan and Laurence Cooper propose that intermolecular cooperativity, a novel mechanism of antibody binding, may help to explain the preferential expression of IgG3 antibodies in these responses.
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页码：164 / 168
页数：5
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