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IMMUNOCHARACTERIZATION OF DELTA-ISOENZYMES AND ZETA-ISOENZYMES OF PROTEIN-KINASE-C IN RAT RENAL MESANGIAL CELLS

被引：71
作者：
HUWILER, A
FABBRO, D
STABEL, S
PFEILSCHIFTER, J
机构：
[1] UNIV BASEL,BIOCTR,DEPT PHARMACOL,KLINGELBERGSTR 70,CH-4056 BASEL,SWITZERLAND
[2] CIBA GEIGY AG,RES DEPT,DIV PHARMACEUT,CH-4002 BASEL,SWITZERLAND
[3] MAX PLANCK GESELL,MAX DELBRUCK LAB,W-5000 COLOGNE 30,GERMANY
来源：
FEBS LETTERS | 1992年 / 300卷 / 03期
关键词：
PROTEIN KINASE-C; ISOENZYME; MESANGIAL CELL;
D O I：
10.1016/0014-5793(92)80858-E
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The isoforms of protein kinase C (PKC) present in rat mesangial cells were identified by immunoblot analysis with antibody raised against isotype-specific peptides. In addition to the previously observed alpha- and epsilon-subspecies, mesangial cells also express the delta-and zeta-isoenzymes of PKC. On exposure to phorbol 12,13-dibutyrate (PDB) a complete depletion of PKC-delta is observed within 8 h. Removal of PDB results in a recovery of PKC-delta. In contrast, PKC-zeta is unaffected by addition or removal of PDB.
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页码：259 / 262
页数：4
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