CLUSTERING OF C2-H2 ZINC FINGER MOTIF SEQUENCES WITHIN TELOMERIC AND FRAGILE SITE REGIONS OF HUMAN-CHROMOSOMES

被引：50

作者：

LICHTER, P

BRAY, P

RIED, T

DAWID, IB

WARD, DC

机构：

[1] YALE UNIV,SCH MED,DEPT GENET,333 CEDAR ST,NEW HAVEN,CT 06510

[2] YALE UNIV,SCH MED,DEPT MOLEC BIOPHYS & BIOCHEM,NEW HAVEN,CT 06510

[3] NICHHD,MOLEC GENET LAB,BETHESDA,MD 20892

[4] DEUTSCH KREBSFORSCHUNGSZENTRUM,INST VIRUSFORSCH,W-6900 HEIDELBERG,GERMANY

来源：

GENOMICS | 1992年 / 13卷 / 04期

关键词：

D O I：

10.1016/0888-7543(92)90013-I

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ninety-three phage clones identified by hybridization with a C2H2 zinc finger sequence probe have been grouped into 23 genetic loci. Partial sequencing verified that each locus belonged to the zinc finger family. Oligonucleotide primer pairs were developed from these sequences to serve as STS markers for these loci. One or more clones from each locus was mapped onto human metaphase chromosomes by fluorescence in situ hybridization. Several loci map to identical chromosomal regions, indicating the possible presence of multigene clusters. Zinc finger loci were found to reside predom nantly either in telomeric regions or in chromosomal bands known to exhibit chromosome fragility. Chromosome 19 carries a disproportionate fraction (10 of 23) of the mapped zinc finger loci. © 1992.

引用

页码：999 / 1007

页数：9

共 48 条

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