CLUSTERING OF C2-H2 ZINC FINGER MOTIF SEQUENCES WITHIN TELOMERIC AND FRAGILE SITE REGIONS OF HUMAN-CHROMOSOMES

被引：50

作者：

LICHTER, P

BRAY, P

RIED, T

DAWID, IB

WARD, DC

机构：

[1] YALE UNIV,SCH MED,DEPT GENET,333 CEDAR ST,NEW HAVEN,CT 06510

[2] YALE UNIV,SCH MED,DEPT MOLEC BIOPHYS & BIOCHEM,NEW HAVEN,CT 06510

[3] NICHHD,MOLEC GENET LAB,BETHESDA,MD 20892

[4] DEUTSCH KREBSFORSCHUNGSZENTRUM,INST VIRUSFORSCH,W-6900 HEIDELBERG,GERMANY

来源：

GENOMICS | 1992年 / 13卷 / 04期

关键词：

D O I：

10.1016/0888-7543(92)90013-I

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ninety-three phage clones identified by hybridization with a C2H2 zinc finger sequence probe have been grouped into 23 genetic loci. Partial sequencing verified that each locus belonged to the zinc finger family. Oligonucleotide primer pairs were developed from these sequences to serve as STS markers for these loci. One or more clones from each locus was mapped onto human metaphase chromosomes by fluorescence in situ hybridization. Several loci map to identical chromosomal regions, indicating the possible presence of multigene clusters. Zinc finger loci were found to reside predom nantly either in telomeric regions or in chromosomal bands known to exhibit chromosome fragility. Chromosome 19 carries a disproportionate fraction (10 of 23) of the mapped zinc finger loci. © 1992.

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收藏

页码：999 / 1007

页数：9

相关论文

共 48 条

[21] ORIGIN OF HUMAN CHROMOSOME-2 - AN ANCESTRAL TELOMERE TELOMERE FUSION [J].

IJDO, JW ;

BALDINI, A ;

WARD, DC ;

REEDERS, ST ;

WELLS, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (20) :9051-9055

[22] ISOLATION OF CDNA-ENCODING TRANSCRIPTION FACTOR SP1 AND FUNCTIONAL-ANALYSIS OF THE DNA-BINDING DOMAIN [J].

KADONAGA, JT ;

CARNER, KR ;

MASIARZ, FR ;

TIJIAN, R .

CELL, 1987, 51 (06) :1079-1090

[23] THE GLI GENE IS A MEMBER OF THE KRUPPEL FAMILY OF ZINC FINGER PROTEINS [J].

KINZLER, KW ;

RUPPERT, JM ;

BIGNER, SH ;

VOGELSTEIN, B .

NATURE, 1988, 332 (6162) :371-374

[24] ZINC FINGERS - A NOVEL PROTEIN MOTIF FOR NUCLEIC-ACID RECOGNITION [J].

KLUG, A ;

RHODES, D .

TRENDS IN BIOCHEMICAL SCIENCES, 1987, 12 (12) :464-469

[25] PCR-KARYOTYPE OF HUMAN-CHROMOSOMES IN SOMATIC-CELL HYBRIDS [J].

LEDBETTER, SA ;

GARCIAHERAS, J ;

LEDBETTER, DH .

GENOMICS, 1990, 8 (04) :614-622

[26] FLUORESCENCE INSITU HYBRIDIZATION WITH ALU AND L1 POLYMERASE CHAIN-REACTION PROBES FOR RAPID CHARACTERIZATION OF HUMAN-CHROMOSOMES IN HYBRID CELL-LINES [J].

LICHTER, P ;

LEDBETTER, SA ;

LEDBETTER, DH ;

WARD, DC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6634-6638

[27] ANALYSIS OF GENES AND CHROMOSOMES BY NONISOTOPIC INSITU HYBRIDIZATION [J].

LICHTER, P ;

BOYLE, AL ;

CREMER, T ;

WARD, DC .

GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING, 1991, 8 (01) :24-35

[28] DELINEATION OF INDIVIDUAL HUMAN-CHROMOSOMES IN METAPHASE AND INTERPHASE CELLS BY INSITU SUPPRESSION HYBRIDIZATION USING RECOMBINANT DNA LIBRARIES [J].

LICHTER, P ;

CREMER, T ;

BORDEN, J ;

MANUELIDIS, L ;

WARD, DC .

HUMAN GENETICS, 1988, 80 (03) :224-234

[29] HIGH-RESOLUTION MAPPING OF HUMAN CHROMOSOME-11 BY INSITU HYBRIDIZATION WITH COSMID CLONES [J].

LICHTER, P ;

TANG, CJC ;

CALL, K ;

HERMANSON, G ;

EVANS, GA ;

HOUSMAN, D ;

WARD, DC .

SCIENCE, 1990, 247 (4938) :64-69

[30] REPRODUCIBLE COMPARTMENTALIZATION OF INDIVIDUAL CHROMOSOME DOMAINS IN HUMAN CNS CELLS REVEALED BY INSITU HYBRIDIZATION AND 3-DIMENSIONAL RECONSTRUCTION [J].

MANUELIDIS, L ;

BORDEN, J .

CHROMOSOMA, 1988, 96 (06) :397-410

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