EFFECTS OF LITHIUM AND RUBIDIUM ON IMMUNE-RESPONSES OF RATS

被引：14

作者：

JONES, JM

YERALAN, O

HINES, G

MAHER, M

ROBERTS, DW

BENSON, RW

机构：

[1] NATL CTR TOXICOL RES,DIV BIOCHEM TOXICOL,HFT-110,JEFFERSON,AR 72079

[2] UNIV ARKANSAS MED SCI HOSP,DEPT PATHOL,LITTLE ROCK,AR 72205

[3] UNIV ARKANSAS MED SCI HOSP,DEPT MICROBIOL IMMUNOL,LITTLE ROCK,AR 72205

[4] UNIV ARKANSAS,DEPT PSYCHOL,LITTLE ROCK,AR 72204

来源：

TOXICOLOGY LETTERS | 1990年 / 52卷 / 02期

关键词：

Immune responses; Lithium; Rats; Rubidium;

D O I：

10.1016/0378-4274(90)90150-K

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Rats were treated with LiCl or RbCl in drinking water for 65 days. Spleen cells from both treated groups exhibited significantly greater proliferative responses to lipopolysaccharide (LPS) than those from untreated controls. Responses to concanavalin A (Con A) were not affected. Cytotoxic activities of natural killer (NK) cells from both treated groups were significantly less than those from untreated controls. In vitro, Li augmented responses of spleen cells to LPS, but the same doses of Rb suppressed the responses. Effects on responses to Con A were variable. Both Li and Rb alone had a small mitogenic effect on spleen cells. © 1990.

引用

页码：163 / 168

页数：6

共 20 条

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