SEQUENCE HOMOLOGIES BETWEEN HSP60 AND AUTOANTIGENS

被引：159

作者：

JONES, DB

COULSON, AFW

DUFF, GW

机构：

[1] ARROWE PK HOSP,DEPT IMMUNOL,LIVERPOOL L49 5PG,MERSEYSIDE,ENGLAND

[2] ROYAL LIVERPOOL HOSP,DEPT MED,LIVERPOOL L49 5PG,MERSEYSIDE,ENGLAND

[3] ROYAL LIVERPOOL HOSP,DEPT IMMUNOL,LIVERPOOL L49 5PG,MERSEYSIDE,ENGLAND

[4] UNIV EDINBURGH,INST CELL & MOLEC BIOL,EDINBURGH EH9 3JR,MIDLOTHIAN,SCOTLAND

[5] UNIV SHEFFIELD,ROYAL HALLAMSHIRE HOSP,DEPT MOLEC MED,SHEFFIELD S10 2JE,ENGLAND

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 03期

关键词：

D O I：

10.1016/0167-5699(93)90210-C

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human heat shock protein (hsp) 60 shares sequence homology with a wide range of autoantigens including those of insulin dependent diabetes mellitus, Hashimoto's thyroiditis, glomerulonephritis, scleroderma, pemphigoid, rheumatoid arthritis, multiple sclerosis, chronic active hepatitis, primary biliary cirrhosis and Addison's disease. Here we show the extent of this homology and suggest that it contributes to autoimmunity through cross-reactivity between hsp60 and tissue-specific proteins containing similar epitope motifs. Differences between individuals in MHC class II may influence the selection of a particular hsp60 epitope and the corresponding target antigen that gives rise to an autoimmune disease.

引用

页码：115 / 118

页数：4

共 33 条

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