2-AMINO-1-PHENYL-1,3-PROPANEDIOL DERIVATIVES - NEW LIGANDS FOR ASYMMETRIC 1,4-ADDITION OF ORGANOZINC REAGENTS TO ENONES

被引：20

作者：

FUJISAWA, T

ITOH, S

SHIMIZU, M

机构：

来源：

CHEMISTRY LETTERS | 1994年 / 10期

关键词：

D O I：

10.1246/cl.1994.1777

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the presence of (1S,2S)-3-benzyloxy-2-morpholino-1-phenylpropanol derived readily from (1S,2S)-2-amino-1-phenyl-1,3-propanediol and nickel acetylacetonate, diethylzinc added to alpha,beta-unsaturated ketones to give alkylated product in high optical purity (up to 95%ee). The effects of solvents and additives and the use of such ligands as a chiral catalyst were also investigated.

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页码：1777 / 1780

页数：4

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