TOWARDS THE ELUCIDATION OF THE STRUCTURAL-FUNCTIONAL RELATIONSHIP OF INWARD RECTIFYING K+ CHANNEL FAMILY

被引：10

作者：

KUBO, Y

机构：

[1] Department of Neurophysiology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, 183

来源：

NEUROSCIENCE RESEARCH | 1994年 / 21卷 / 02期

关键词：

INWARD RECTIFIER K+ CHANNEL; MUSCARINIC K+ CHANNEL; CDNA CLONING; MG2+ BLOCK; INTRINSIC GATING; BLOCKING PARTICLE MODEL; K+-ACTIVATED K+ CHANNEL MODEL; TRIPLE-BARREL STRUCTURE; GTP BINDING PROTEIN; GTPASE ACTIVATING PROTEIN;

D O I：

10.1016/0168-0102(94)90152-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

With recent cDNA cloning of members of the inward rectifying K+ channel family, it was revealed that they have only 2 putative transmembrane regions with no voltage-sensor dement. Based on the deduced primary structure, possible schematic models to explain their characteristic features are proposed in this article. The features are (1) blocking by intracellular Mg2+, (2) intrinsic gating, (3) the triple barrel structure of the inward rectifier K+ channel and (4) the activation by the direct interaction with G-protein subunits of the muscarinic K+ channel. The recent findings of the mutagenesis study of voltage-gated K+ channels, which provide a due for the structural-functional study of the inward rectifying K+ channels, are also looked at.

引用

页码：109 / 117

页数：9

共 76 条

[11] A SINGLE NEGATIVE CHARGE WITHIN THE PORE REGION OF A CGMP-GATED CHANNEL CONTROLS RECTIFICATION, CA2+ BLOCKAGE, AND IONIC SELECTIVITY [J].