ATRIAL-NATRIURETIC-PEPTIDE GENE-EXPRESSION IN THE RAT GASTROINTESTINAL-TRACT

被引:35
作者
GOWER, WR
DIETZ, JR
VESELY, DL
FINLEY, CL
SKOLNICK, KA
FABRI, PJ
COOPER, DR
CHALFANT, CE
机构
[1] JAMES A HALEY VET HOSP,MED SERV,TAMPA,FL 33612
[2] JAMES A HALEY VET HOSP,RES SERV,TAMPA,FL 33612
[3] JAMES A HALEY VET HOSP,SURG SERV,TAMPA,FL 33612
[4] UNIV S FLORIDA,HLTH SCI CTR,DEPT BIOCHEM & MOLEC BIOL,TAMPA,FL 33612
[5] UNIV S FLORIDA,HLTH SCI CTR,DEPT PHYSIOL & BIOPHYS,TAMPA,FL 33612
[6] UNIV S FLORIDA,HLTH SCI CTR,DEPT INTERNAL MED,TAMPA,FL 33612
[7] UNIV S FLORIDA,HLTH SCI CTR,DEPT SURG,TAMPA,FL 33612
关键词
D O I
10.1006/bbrc.1994.1965
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The presence of ANP prohormone immunoreactivity in rat GI tract suggests that it may be an extracardiac site of ANP synthesis. The aim of this study was to investigate the expression of ANP mRNA in the adult rat GI tract. ANP mRNA was detected by ribonuclease protection analysis in stomach, small and large intestines, and rectum/anus. The highest concentrations of ANP transcripts were found in the proximal stomach, antrum, proximal colon, and rectum/anus at levels that ranged from 1 to 10% of that found in cardiac ventricle. Northern blot analysis of total RNA from these tissues identified a single 0.9 kb ANP transcript similar to that detected in heart. Gel filtration chromatography of tissue extracts provided evidence for the presence of the complete ANP prohormone in proximal stomach, antrum, proximal colon and rectum/anus. These results demonstrate that the gene for ANP is expressed in specific regions of the rat GI tract,suggesting that tissue-specific differential regulation of ANP synthesis occurs within the GI tract. (C) 1994 Academic Press, Inc.
引用
收藏
页码:562 / 570
页数:9
相关论文
共 40 条
[11]  
GODELLAS CV, 1991, SURGERY, V110, P1022
[12]  
GOWER WR, 1994, IN PRESS PEPTIDES
[13]   HISTAMINE IS NOT INVOLVED IN PENTAGASTRIN-INDUCED GASTRIC-MUCOSAL VASODILATION IN THE RAT [J].
HOLM, L ;
JAGARE, A .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (01) :G55-G61
[14]   EFFECTS OF OMEPRAZOLE ON GASTRIC-MUCOSAL MICROCIRCULATION AND ACID-SECRETION IN THE RAT [J].
HOLMRUTILI, L .
GASTROENTEROLOGY, 1987, 92 (03) :716-723
[15]   SPECIFIC GRANULES IN ATRIAL MUSCLE CELLS [J].
JAMIESON, JD ;
PALADE, GE .
JOURNAL OF CELL BIOLOGY, 1964, 23 (01) :151-+
[16]  
JANUSZEWICZ P, 1985, P SOC EXP BIOL MED, V178, P321
[17]   RAT ATRIAL NATRIURETIC POLYPEPTIDE INCREASES NET WATER, SODIUM AND CHLORIDE ABSORPTION ACROSS RAT SMALL-INTESTINE INVIVO [J].
KANAI, Y ;
OHNUMA, N ;
MATSUO, H .
JAPANESE JOURNAL OF PHARMACOLOGY, 1987, 45 (01) :7-13
[18]   AN EMERGING RELATIONSHIP BETWEEN PERIPHERAL SYMPATHETIC NERVOUS ACTIVITY AND ATRIAL-NATRIURETIC-FACTOR [J].
KUCHEL, O ;
DEBINSKI, W ;
RACZ, K ;
BUU, NT ;
GARCIA, R ;
CUSSON, JR ;
LAROCHELLE, P ;
CANTIN, M ;
GENEST, J .
LIFE SCIENCES, 1987, 40 (16) :1545-1551
[19]   LOCALIZATION OF SPECIFIC BINDING-SITES FOR ATRIAL-NATRIURETIC-FACTOR IN PERIPHERAL-TISSUES OF THE GUINEA-PIG, RAT, AND HUMAN [J].
MANTYH, CR ;
KRUGER, L ;
BRECHA, NC ;
MANTYH, PW .
HYPERTENSION, 1986, 8 (08) :712-721
[20]  
MORIARTY KJ, 1989, ION TRANSPORT, P50