5-PARA-BENZOQUINONYL-2'-DEOXYURIDINE 5'-PHOSPHATE - A POSSIBLE MECHANISM-BASED INHIBITOR OF THYMIDYLATE SYNTHETASE

被引：9

作者：

MAGGIORA, L ^{[1
]}

CHANG, CTC ^{[1
]}

HASSON, ME ^{[1
]}

BIGGE, CF ^{[1
]}

MERTES, MP ^{[1
]}

机构：

[1] UNIV KANSAS,SCH PHARM,DEPT MED CHEM,LAWRENCE,KS 66045

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1983年 / 26卷 / 07期

关键词：

D O I：

10.1021/jm00361a016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1028 / 1036

页数：9

共 42 条

[31] CHEMISTRY AND ENZYMOLOGY OF KCAT INHIBITORS [J].

RANDO, RR .

SCIENCE, 1974, 185 (4148) :320-324

[32] MECHANISMS OF ACTION OF NATURALLY OCCURRING IRREVERSIBLE ENZYME-INHIBITORS [J].

RANDO, RR .

ACCOUNTS OF CHEMICAL RESEARCH, 1975, 8 (08) :281-288

[33] AN ISOTOPIC ASSAY FOR THYMIDYLATE SYNTHETASE [J].

ROBERTS, D .

BIOCHEMISTRY, 1966, 5 (11) :3546-&

[34] C-5 SUBSTITUTED PYRIMIDINE NUCLEOSIDES .1. SYNTHESIS OF C-5 ALLYL, PROPYL, AND PROPENYL URACIL AND CYTOSINE NUCLEOSIDES VIA ORGANOPALLADIUM INTERMEDIATES [J].

RUTH, JL ;

BERGSTROM, DE .

JOURNAL OF ORGANIC CHEMISTRY, 1978, 43 (14) :2870-2876

[35] 5-FLUORO-2'-DEOXYURIDYLATE - COVALENT COMPLEX WITH THYMIDYLATE SYNTHETASE [J].

SANTI, DV ;

MCHENRY, CS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (07) :1855-&

[36] MECHANISM OF INTERACTION OF THYMIDYLATE SYNTHETASE WITH 5-FLUORODEOXYURIDYLATE [J].

SANTI, DV ;

MCHENRY, CS ;

SOMMER, H .

BIOCHEMISTRY, 1974, 13 (03) :471-481

[37] OXIDATIVE CLEAVAGE OF HYDROQUINONE ETHERS WITH ARGENTIC OXIDE [J].

SNYDER, CD ;

RAPOPORT, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1972, 94 (01) :227-&

[38] FACILE SYNTHESIS OF 5'-NUCLEOTIDES BY SELECTIVE PHOSPHORYLATION OF A PRIMARY HYDROXYL GROUP OF NUCLEOSIDES WITH PHOSPHORYL CHLORIDE [J].

SOWA, T ;

OUCHI, S .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1975, 48 (07) :2084-2090

[39]

WATAYA Y, 1980, J BIOL CHEM, V255, P5538

[40]

WEBB JL, 1966, ENZYMES METABOL INH, V3, P421

← 1 2 3 4 5 →