RESIDUAL SPERM FUNCTION IN OLIGOZOOSPERMIA INDUCED BY TESTOSTERONE ENANTHATE ADMINISTERED AS A POTENTIAL STEROID MALE CONTRACEPTIVE

被引：25

作者：

WALLACE, EM ^{[1
]}

AITKEN, RJ ^{[1
]}

WU, FCW ^{[1
]}

机构：

[1] MRC,DEPT REPROD BIOL,REPROD BIOL UNIT,37 CHALMERS ST,EDINBURGH EH3 9EW,MIDLOTHIAN,SCOTLAND

来源：

INTERNATIONAL JOURNAL OF ANDROLOGY | 1992年 / 15卷 / 05期

关键词：

HAMSTER OOCYTE PENETRATION TEST; MALE CONTRACEPTION; SPERMATOZOA; TESTOSTERONE;

D O I：

10.1111/j.1365-2605.1992.tb01356.x

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

To investigate the fertility of men who remain oligozoospermic despite sex steroid suppression, the in-vitro fertilizing capacity of residual spermatozoa was assessed in 30 men receiving intramuscular testosterone enanthate (TE). Spermatozoa were prepared by either Percoll or repetitive centrifugation/washing. Although the mean ( +/- SEM) pretreatment zona-free hamster oocyte penetration (HOP) rates were similar (59.4 +/- 10.1 and 63.8 +/- 10.8%), following the induction of oligozoospermia the Percoll-prepared spermatozoa exhibited a penetration rate (26.9 +/- 10.2%) which was markedly greater than that obtained for sperm prepared by repetitive washing (0 +/- 0%). In addition, the partners of two men exhibiting a HOP test with Percoll-prepared spermatozoa, conceived despite a sperm concentration of 3 x (10)6 ml-1 and a negative HOP test with spermatozoa prepared by repetitive washing. These results suggest that Percoll preparation optimizes the assessment of in-vitro sperm function and that the fertility of men with TE-induced severe oligozoospermia is suppressed but not abolished.

引用

页码：416 / 424

页数：9