SOLUTION CONFORMATION OF THE TETRASACCHARIDE GLYCOSIDE XYL-BETA-1-(MAN-ALPHA-1-3)2MAN-BETA-1-4GLC-BETA-1R FROM THE MOLLU-SERIES GLYCOSPHINGOLIPIDS

被引：7

作者：

DABROWSKI, U

DABROWSKI, J

GROSSKURTH, H

VONDERLIETH, CW

OGAWA, T

机构：

[1] GERMAN CANC RES CTR, W-6900 HEIDELBERG 1, GERMANY

[2] RIKEN, WAKO, SAITAMA 35101, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 192卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1524

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The conformation of Xylβ1-(Manα1-3)2Manβ1-4Glcβ1- OCH2CH(N3)CH(OH)CH=CHC13H27 tetrasaccharide glycoside in Me2SO-d6 was investigated with use of a distance mapping procedure based on rotating- frame NOE and hydrogen bond constraints, and Molecular Mechanics calculations. The Manα1-3Manβ linkage was found to be well defined in a single information, whereas some flexibility could be assumed for the remaining two glycosidic linkages. Similar conclusions, though based on a smaller number of constraints, were drawn for the title compound anchored in mixed D2O/dodecylphosphocholine-d38 micelles. © 1993 Academic Press, Inc.

引用

页码：1057 / 1065

页数：9

共 29 条

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