AN INTERSTITIAL DELETION IN MOUSE-Y CHROMOSOMAL DNA CREATED A TRANSCRIBED ZFY FUSION GENE

被引：50

作者：

SIMPSON, EM ^{[1
]}

PAGE, DC ^{[1
]}

机构：

[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02142

来源：

GENOMICS | 1991年 / 11卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0888-7543(91)90067-O

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The small portion of the mouse Y chromosome retained in the Sxra transposition is thought to carry at least five genes including, as demonstrated here, the entirety of the zincfinger genes Zfy-1 and Zfy-2. Sxrb, a derivative of Sxra, was previously thought to retain Zfy-1 but to be deleted for Zfy-2. Here we show that Sxrb differs from Sxra as the result of unequal crossing-over between Zfy-1 and Zfy-2. This unequal crossing-over created a transcribed Zfy- 2 1 fusion gene and an interstitial deletion. Our data and previous results together suggest that this deletion encompassed the 3′ portion of Zfy-2, the histocompatibility gene Hya, the spermatogenesis factor Spy, and the 5′ portion of Zfy-1. We suggest that not only Zfy but also other neighboring genes such as Spy and Hya may exist in two copies on the Y as the result of a large tandem duplication during rodent evolution. © 1991.

引用

页码：601 / 608

页数：8