AUTOANTIBODIES, NEUROTOXINS AND THE NERVOUS-SYSTEM

被引：14

作者：

VINCENT, A ^{[1
]}

ROBERTS, M ^{[1
]}

WILLISON, H ^{[1
]}

LANG, B ^{[1
]}

NEWSOMDAVIS, J ^{[1
]}

机构：

[1] UNIV GLASGOW, DEPT NEUROL, GLASGOW G61 1BD, LANARK, SCOTLAND

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1995年 / 89卷 / 03期

基金：

英国医学研究理事会;

关键词：

ION CHANNELS; NEUROTOXINS; AUTOANTIBODY; GANGLIOSIDES; NEUROMUSCULAR JUNCTION;

D O I：

10.1016/0928-4257(96)80110-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Myasthenia gravis, the Lambert-Eaton myasthenic syndrome, and acquired neuromyotonia are three disorders of the neuromuscular junction or motor nerve that are caused by autoantibodies to ion channel proteins: acetylcholine receptors, voltage-gated calcium channels and voltage-gated potassium channels, respectively. The antibody titres can be measured using the relevant I-125-neurotoxins to label the extracted channels. Other disorders of the peripheral motor nerve are associated with antibodies to gangliosides. Sera with raised levels of anti-ganglioside antibodies have direct effects on the function of the distal motor nerve and motor nerve terminal. These conditions can be improved by therapies designed to reduce circulating antibodies. Antibodies that bind to neuronal surface antigens are proving to be of great clinical importance and interest in neurological disorders.

引用

页码：129 / 136

页数：8

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