ONTOGENY OF VASOACTIVE-INTESTINAL-PEPTIDE RECEPTORS IN RAT VENTRAL PROSTATE

被引：22

作者：

JUARRANZ, MG ^{[1
]}

GUIJARRO, LG ^{[1
]}

BAJO, AM ^{[1
]}

CARMENA, MJ ^{[1
]}

PRIETO, JC ^{[1
]}

机构：

[1] UNIV ALCALA DE HENARES, DEPT BIOQUIM & BIOL MOLEC, UNIDAD NEUROENDOCRINOL MOLEC, E-28871 ALCALA DE HENARES, SPAIN

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1994年 / 25卷 / 03期

关键词：

D O I：

10.1016/0306-3623(94)90207-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The stimulatory effect of VIP on rat prostatic adenylyl cyclase changes during postnatal development. It peaks at 2 months (peripubertal period), remains in a plateau between 3 and 12 months (adult period), and decreases at 24 months (old period). 2. The stimulation of rat prostatic adenylylcyclase by the beta-adrenergic agonist isoproterenol follows a pattern rather similar to that of VIP. 3. The values of VIP binding capacity correlate well with those observed for adenylyl cyclase between 1 and 12 months, whereas there appears to exist a great number of uncoupled VIP receptors at 0.5 and 24 months. 4. The apparent molecular mass (51 kDa) of the rat prostatic VIP-receptor complex remains unaltered during ontogenic development.

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收藏

页码：509 / 514

页数：6

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