THE ROLE OF CYTOKINES IN THE IMMUNOPATHOGENESIS OF LUPUS

被引：46

作者：

HANDWERGER, BS

RUS, V

DASILVA, L

VIA, CS

机构：

[1] UNIV MARYLAND, SCH MED, DEPT MED, DIV CLIN IMMUNOL & RHEUMATOL, BALTIMORE, MD 21201 USA

[2] UNIV MARYLAND, SCH MED, DEPT MICROBIOL & IMMUNOL, BALTIMORE, MD 21201 USA

[3] DEPT VET AFFAIRS MED CTR, BALTIMORE, MD 21201 USA

来源：

SPRINGER SEMINARS IN IMMUNOPATHOLOGY | 1994年 / 16卷 / 2-3期

关键词：

D O I：

10.1007/BF00197515

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Increasing data suggest that human and murine lupus are heterogeneous diseases and that, in genetically susceptible individuals, lupus may be the final common pathway of a number of etiological agents and/or immunological processes. This review has discussed a number of cytokines which appear to be involved in lupus pathogenesis. The models that we have put forward illustrate several possible mechanisms which may lead to lupus. During the next several years, the exact role of these cytokine in the pathogenesis of lupus should become more fully elucidated. Hopefully, this knowledge will provide the framework for newer, highly specific immunotherapeutic approaches to the treatment of this fascinating, complex, and potentially devastating disease. © 1994 Springer-Verlag.

引用

页码：153 / 180

页数：28

共 214 条

[101] CORRECTION OF INTERLEUKIN-2 PRODUCTION IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS BY REMOVAL OF SPONTANEOUSLY ACTIVATED SUPPRESSOR CELLS [J].