GP120 NEUROTOXICITY IN PRIMARY CORTICAL CULTURES

被引：22

作者：

DAWSON, TM

DAWSON, VL

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21287

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PHYSIOL,BALTIMORE,MD 21287

来源：

ADVANCES IN NEUROIMMUNOLOGY | 1994年 / 4卷 / 03期

关键词：

D O I：

10.1016/S0960-5428(06)80253-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human immunodeficiency virus type 1 coat protein, gp120, kills neurons in a nitric oxide dependent manner in primary cortical cultures at low picomolar concentrations. gp120 neurotoxicity also requires calcium and glutamate and is blocked by glutamate receptor antagonists. In addition, superoxide anions play a role in gp120 neurotoxicity since superoxide dismutase also attenuates neurotoxicity.

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收藏

页码：167 / 173

页数：7

相关论文

共 45 条

[1] APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].

BECKMAN, JS ;

BECKMAN, TW ;

CHEN, J ;

MARSHALL, PA ;

FREEMAN, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1620-1624

[2]

BECKMAN JS, 1991, J DEV PHYSIOL, V15, P53

[3] NEURONAL CELL KILLING BY THE ENVELOPE PROTEIN OF HIV AND ITS PREVENTION BY VASOACTIVE INTESTINAL PEPTIDE [J].

BRENNEMAN, DE ;

WESTBROOK, GL ;

FITZGERALD, SP ;

ENNIST, DL ;

ELKINS, KL ;

RUFF, MR ;

PERT, CB .

NATURE, 1988, 335 (6191) :639-642

[4] SUPEROXIDE AND NITRIC-OXIDE COOPERATION IN HYPOXIA REOXYGENATION-INDUCED NEURON INJURY [J].

CAZEVIEILLE, C ;

MULLER, A ;

MEYNIER, F ;

BONNE, C .

FREE RADICAL BIOLOGY AND MEDICINE, 1993, 14 (04) :389-395

[5] GLUTAMATE NEUROTOXICITY AND DISEASES OF THE NERVOUS-SYSTEM [J].

CHOI, DW .

NEURON, 1988, 1 (08) :623-634

[6] EVIDENCE THAT CHP100 NEUROBLASTOMA CELL-DEATH INDUCED BY N-METHYL-D-ASPARTATE INVOLVES L-ARGININE-NITRIC OXIDE PATHWAY ACTIVATION [J].

CORASANITI, MT ;

TARTAGLIA, RL ;

MELINO, G ;

NISTICO, G ;

FINAZZIAGRO, A .

NEUROSCIENCE LETTERS, 1992, 147 (02) :221-223

[7] IMMUNOSUPPRESSANT FK506 ENHANCES PHOSPHORYLATION OF NITRIC-OXIDE SYNTHASE AND PROTECTS AGAINST GLUTAMATE NEUROTOXICITY [J].

DAWSON, TM ;

STEINER, JP ;

DAWSON, VL ;

DINERMAN, JL ;

UHL, GR ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :9808-9812

[8] A NOVEL NEURONAL MESSENGER MOLECULE IN BRAIN - THE FREE-RADICAL, NITRIC-OXIDE [J].

DAWSON, TM ;

DAWSON, VL ;

SNYDER, SH .

ANNALS OF NEUROLOGY, 1992, 32 (03) :297-311

[9] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 COAT PROTEIN NEUROTOXICITY MEDIATED BY NITRIC-OXIDE IN PRIMARY CORTICAL CULTURES [J].

DAWSON, VL ;

DAWSON, TM ;

UHL, GR ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) :3256-3259

[10]

DAWSON VL, 1993, J NEUROSCI, V13, P2651

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