GP120 NEUROTOXICITY IN PRIMARY CORTICAL CULTURES

被引：22

作者：

DAWSON, TM

DAWSON, VL

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21287

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PHYSIOL,BALTIMORE,MD 21287

来源：

ADVANCES IN NEUROIMMUNOLOGY | 1994年 / 4卷 / 03期

关键词：

D O I：

10.1016/S0960-5428(06)80253-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human immunodeficiency virus type 1 coat protein, gp120, kills neurons in a nitric oxide dependent manner in primary cortical cultures at low picomolar concentrations. gp120 neurotoxicity also requires calcium and glutamate and is blocked by glutamate receptor antagonists. In addition, superoxide anions play a role in gp120 neurotoxicity since superoxide dismutase also attenuates neurotoxicity.

引用

收藏

页码：167 / 173

页数：7

相关论文

共 45 条

[21] MODELS OF NEURONAL INJURY IN AIDS - ANOTHER ROLE FOR THE NMDA RECEPTOR [J].

LIPTON, SA .

TRENDS IN NEUROSCIENCES, 1992, 15 (03) :75-79

[22] SYNERGISTIC EFFECTS OF HIV COAT PROTEIN AND NMDA RECEPTOR-MEDIATED NEUROTOXICITY [J].

LIPTON, SA ;

SUCHER, NJ ;

KAISER, PK ;

DREYER, EB .

NEURON, 1991, 7 (01) :111-118

[23]

LUSTIG HS, 1992, J NEUROCHEM, V59, P2193

[24] EXCITATORY AMINO-ACID NEUROTOXICITY AND NEURODEGENERATIVE DISEASE [J].

MELDRUM, B ;

GARTHWAITE, J .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (09) :379-387

[25]

Michaels J, 1988, Immunodefic Rev, V1, P71

[26] MICROGLIA IN THE GIANT-CELL ENCEPHALITIS OF ACQUIRED IMMUNE-DEFICIENCY SYNDROME - PROLIFERATION, INFECTION AND FUSION [J].

MICHAELS, J ;

PRICE, RW ;

ROSENBLUM, MK .

ACTA NEUROPATHOLOGICA, 1988, 76 (04) :373-379

[27] POTENTIATION OF NMDA RECEPTOR CURRENTS BY ARACHIDONIC-ACID [J].

MILLER, B ;

SARANTIS, M ;

TRAYNELIS, SF ;

ATTWELL, D .

NATURE, 1992, 355 (6362) :722-725

[28]

MONCADA C, 1992, NEUROREPORT, V3, P530

[29] THE AIDS DEMENTIA COMPLEX .2. NEUROPATHOLOGY [J].

NAVIA, BA ;

CHO, ES ;

PETITO, CK ;

PRICE, RW .

ANNALS OF NEUROLOGY, 1986, 19 (06) :525-535

[30] THE AIDS DEMENTIA COMPLEX .1. CLINICAL-FEATURES [J].

NAVIA, BA ;

JORDAN, BD ;

PRICE, RW .

ANNALS OF NEUROLOGY, 1986, 19 (06) :517-524

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