CIRCLING INDUCED BY INTRAACCUMBENS AMPHETAMINE INJECTIONS

被引：22

作者：

COLLE, LM ^{[1
]}

WISE, RA ^{[1
]}

机构：

[1] CONCORDIA UNIV, DEPT PSYCHOL, CTR STUDIES BEHAV NEUROBIOL, 1455 MAISONNEUVE BLVD W, MONTREAL H3G 1M8, QUEBEC, CANADA

来源：

PSYCHOPHARMACOLOGY | 1991年 / 105卷 / 02期

关键词：

CIRCLING; AMPHETAMINE; NUCLEUS ACCUMBENS; RAT;

D O I：

10.1007/BF02244302

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microinjections of d-amphetamine (5.0, 10.0 and 20.0-mu-g/0.5-mu-l) into the nucleus accumbens caused reliable dose-dependent circling away from the side of injection. Injections of l-amphetamine were not effective, ruling out non-specific effects of pH, osmolarity and the like and also ruling out noradrenergic actions as explanations of the behavioral effects. Injections of d-amphetamine into the ventral caudate were less potent than those into the nucleus accumbens, suggesting nucleus accumbens rather than more dorsal tissue as the site of this behavioral effect. These data suggest that asymmetrical activation of the nucleus accumbens is a sufficient condition to induce circling behavior and raise questions for the commonly accepted view that asymmetrical activation of the caudate is a necessary condition for dopamine dependent circling behavior.

引用

页码：157 / 161

页数：5