MECHANISMS BY WHICH CELLS OF THE OSTEOBLAST LINEAGE CONTROL OSTEOCLAST FORMATION AND ACTIVITY

被引:129
作者
MARTIN, TJ
NG, KW
机构
[1] St. Vincent's Institute of Medical Research, University of Melbourne, Department of Medicine, St. Vincent's Hospital, Melbourne
关键词
OSTEOBLASTS; OSTEOCLASTS; HORMONES; CYTOKINES; HEMATOPOIETIC CELLS;
D O I
10.1002/jcb.240560312
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The cells of bone are of two lineages, the osteoblasts arising from pluri potential mesenchymal cells and osteoclasts from hemopoietic precursors of the monocyte-macrophage series. Resorption of bone by the multinucleate osteoclast requires the generation of new osteoclasts and their activation. Many hormones and cytokines are able to promote bone resorption by influencing these processes, but they achieve this without acting directly on osteoclasts. Most evidence indicates that their actions are mediated by cells of the osteoblast lineage. Evidence for hormone- and cytokine-induced activation of osteoclasts requiring the mediation of osteoblasts comes from studies of resorption by isolated osteoclasts. However, consistent evidence for a specific ''activating factor'' is lacking, and the argument is presented that the isolated osteoclast resorption assays have not been shown convincingly to be assays of osteoclast activation. The view is presented that osteoblast-mediated osteoclast activation is the result of several events in the microenvironment without necessarily requiring the existence of a specific, essential osteoclast activator. On the other hand, a specific promoter of osteoclast differentiation does seem likely to be a product of cells of the stromal/osteoblast series. Evidence in favour of this comes from studies of osteoclast generation in co-cultures of osteoblast/stromal cells with hemopoietic cells. Conflicting views, maintaining that osteoclasts can develop from hemopoietic cells without stromal intervention, might be explained by varying criteria used in identification of osteoclasts. Osteoblastic and osteoclastic renewal, and the interactions of these lineages, are central to the process of bone remodeling. (C) 1994 Wiley-Liss, Inc.
引用
收藏
页码:357 / 366
页数:10
相关论文
共 61 条
[21]   GENERATION OF OSTEOCLASTIC FUNCTION IN MOUSE BONE-MARROW CULTURES - MULTINUCLEARITY AND TARTRATE-RESISTANT ACID-PHOSPHATASE ARE UNRELIABLE MARKERS FOR OSTEOCLASTIC DIFFERENTIATION [J].
HATTERSLEY, G ;
CHAMBERS, TJ .
ENDOCRINOLOGY, 1989, 124 (04) :1689-1696
[22]   HUMAN MACROPHAGE COLONY-STIMULATING FACTOR INHIBITS BONE-RESORPTION BY OSTEOCLASTS DISAGGREGATED FROM RAT BONE [J].
HATTERSLEY, G ;
DOREY, E ;
HORTON, MA ;
CHAMBERS, TJ .
JOURNAL OF CELLULAR PHYSIOLOGY, 1988, 137 (01) :199-203
[23]  
HATTERSLEY G, 1992, BONE MINER S, V17, P199
[24]   DETECTION OF TRANSCRIPTS FOR THE RECEPTOR FOR MACROPHAGE COLONY-STIMULATING FACTOR, C-FMS, IN MURINE OSTEOCLASTS [J].
HOFSTETTER, W ;
WETTERWALD, A ;
CECCHINI, MC ;
FELIX, R ;
FLEISCH, H ;
MUELLER, C .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (20) :9637-9641
[25]   CYTOKINES AND ESTROGEN IN BONE - ANTI-OSTEOPOROTIC EFFECTS [J].
HOROWITZ, MC .
SCIENCE, 1993, 260 (5108) :626-627
[26]   INCREASED OSTEOCLAST DEVELOPMENT AFTER ESTROGEN LOSS - MEDIATION BY INTERLEUKIN-6 [J].
JILKA, RL ;
HANGOC, G ;
GIRASOLE, G ;
PASSERI, G ;
WILLIAMS, DC ;
ABRAMS, JS ;
BOYCE, B ;
BROXMEYER, H ;
MANOLAGAS, SC .
SCIENCE, 1992, 257 (5066) :88-91
[27]  
JONES SJ, 1976, CELL TISSUE RES, V169, P449
[28]  
KALU DN, 1990, P SOC EXP BIOL MED, V195, P70
[29]   IDENTIFICATION OF COMMITTED MONONUCLEAR PRECURSORS FOR OSTEOCLAST-LIKE CELLS FORMED IN LONG-TERM HUMAN MARROW CULTURES [J].
KURIHARA, N ;
CHENU, C ;
MILLER, M ;
CIVIN, C ;
ROODMAN, GD .
ENDOCRINOLOGY, 1990, 126 (05) :2733-2741
[30]  
KURIHARA N, 1989, BLOOD, V74, P1295