SEX-CHROMOSOME ANEUPLOIDY AND AGING

被引：103

作者：

STONE, JF

SANDBERG, AA

机构：

[1] Southwest Biomedical Research Institute, Genetrix, Inc., Scottsdale, AZ 85260

来源：

MUTATION RESEARCH-DNAGING GENETIC INSTABILITY AND AGING | 1995年 / 338卷 / 1-6期

关键词：

X CHROMOSOME; Y CHROMOSOME; AGING; ANEUPLOIDY; PREMATURE CENTROMERE DIVISION; MICRONUCLEATION;

D O I：

10.1016/0921-8734(95)00016-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Loss of an X chromosome in females and of the Y chromosome in males are phenomena associated with aging. X chromosome loss occurs in and may be limited to PHA stimulated peripheral lymphocytes. In males, the loss of the Y is most evident in bone marrow cells, but also occurs to a lesser extent in PHA stimulated peripheral lymphocytes. X chromosome loss is associated with premature centromere division leading to anaphase lag and elimination in micronuclei. The mechanism of Y chromosome loss has not been elucidated. No pathological consequence of either X or Y chromosome loss has been convincingly demonstrated. With the advent of FISH technology, measurement of sex chromosome aneuploidy may prove to be a convenient assay for cellular senecence and aging.

引用

页码：107 / 113

页数：7

共 53 条

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