TREATMENT OF HEREDO-DEGENERATIVE ATAXIAS WITH AMANTADINE HYDROCHLORIDE

被引:35
作者
BOTEZ, MI [1 ]
YOUNG, SN [1 ]
BOTEZ, T [1 ]
PEDRAZA, OL [1 ]
机构
[1] MCGILL UNIV, DEPT PSYCHIAT, MONTREAL H3A 2T5, QUEBEC, CANADA
关键词
D O I
10.1017/S0317167100031863
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Amantadine hydrochloride (AH) was administered (200 mg/day) for more than three months to 17 patients with Friedreich's ataxia (FA) and to 12 patients with olivopontocerebellar atrophies (OPCA) in an open clinical trial. Reaction time (RT) and movement time (MT) with the right and left hand were measured before and after treatment. A striking improvement on both RT and MT was observed in the OPCA group (on seven out of eight measures), whereas in the FA patients improvement was seen only in two out of four MT measures with no improvement in RT. Both groups had low levels of homovanillic acid (HVA) in their cerebrospinal fluid before treatment, relative to their controls. However, improvement with AH was not related to HVA levels.
引用
收藏
页码:307 / 311
页数:5
相关论文
共 43 条
[1]  
AMALRIC M, 1987, J NEUROSCI, V7, P2129
[2]   RAPID LIQUID-CHROMATOGRAPHIC DETERMINATION OF TRYPTOPHAN, TYROSINE, 5-HYDROXYINDOLEACETIC ACID AND HOMOVANILLIC-ACID IN CEREBROSPINAL-FLUID [J].
ANDERSON, GM ;
YOUNG, JG ;
COHEN, DJ .
JOURNAL OF CHROMATOGRAPHY, 1979, 164 (04) :501-505
[3]  
BAK L, 1972, J NEURAL TRANSM, V33, P4561
[4]   SIMPLE REACTION-TIME AND MOVEMENT TIME IN NORMAL HUMAN VOLUNTEERS - A LONG-TERM RELIABILITY STUDY [J].
BAKER, SJ ;
MAURISSEN, JPJ ;
CHRZAN, GJ .
PERCEPTUAL AND MOTOR SKILLS, 1986, 63 (02) :767-774
[5]   PRACTICE EFFECTS IN REACTION-TIME TASKS IN BRAIN-INJURED PATIENTS [J].
BENTON, AL ;
BLACKBURN, HL .
JOURNAL OF ABNORMAL AND SOCIAL PSYCHOLOGY, 1957, 54 (01) :109-113
[6]  
BONNET AM, 1986, CAN J NEUROL SCI, V13, P331
[8]   CEREBELLAR ATROPHY IN EPILEPTIC PATIENTS [J].
BOTEZ, MI ;
ATTIG, E ;
VEZINA, JL .
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1988, 15 (03) :299-303
[9]   REVERSIBLE CHRONIC CEREBELLAR-ATAXIA AFTER PHENYTOIN INTOXICATION - POSSIBLE ROLE OF CEREBELLUM IN COGNITIVE THOUGHT [J].
BOTEZ, MI ;
GRAVEL, J ;
ATTIG, E ;
VEZINA, JL .
NEUROLOGY, 1985, 35 (08) :1152-1157
[10]   ROLE OF THE CEREBELLUM IN COMPLEX HUMAN-BEHAVIOR [J].
BOTEZ, MI ;
BOTEZ, T ;
ELIE, R ;
ATTIG, E .
ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1989, 10 (03) :291-300