TREATMENT OF HEREDO-DEGENERATIVE ATAXIAS WITH AMANTADINE HYDROCHLORIDE

被引：35

作者：

BOTEZ, MI ^{[1
]}

YOUNG, SN ^{[1
]}

BOTEZ, T ^{[1
]}

PEDRAZA, OL ^{[1
]}

机构：

[1] MCGILL UNIV, DEPT PSYCHIAT, MONTREAL H3A 2T5, QUEBEC, CANADA

来源：

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1991年 / 18卷 / 03期

关键词：

D O I：

10.1017/S0317167100031863

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Amantadine hydrochloride (AH) was administered (200 mg/day) for more than three months to 17 patients with Friedreich's ataxia (FA) and to 12 patients with olivopontocerebellar atrophies (OPCA) in an open clinical trial. Reaction time (RT) and movement time (MT) with the right and left hand were measured before and after treatment. A striking improvement on both RT and MT was observed in the OPCA group (on seven out of eight measures), whereas in the FA patients improvement was seen only in two out of four MT measures with no improvement in RT. Both groups had low levels of homovanillic acid (HVA) in their cerebrospinal fluid before treatment, relative to their controls. However, improvement with AH was not related to HVA levels.

引用

页码：307 / 311

页数：5