ON THE MECHANISM OF THE INTERACTION OF KETAMINE AND HALOTHANE INVITRO

被引：8

作者：

BANSINATH, M ^{[1
]}

WARNER, W ^{[1
]}

TANG, CK ^{[1
]}

TURNDORF, H ^{[1
]}

PUIG, MM ^{[1
]}

机构：

[1] NYU,SCH DENT,DEPT PHARMACOL,NEW YORK,NY 10016

来源：

GENERAL PHARMACOLOGY | 1992年 / 23卷 / 06期

关键词：

D O I：

10.1016/0306-3623(92)90309-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Electrically induced contraction of guinea pig ileum myenteric plexus-longitudinal muscle was inhibited by ketamine and halothane with IC50s of 2.1 x 10(-4)M and 1.8 v/v% respectively. 2. The inhibitory action of ketamine was partially antagonized by naloxone and the selective kappa antagonist nor-binaltorphimine. 3. The actions of ketamine and halothane were synergistic at high levels of response (above 30% inhibition). 4. The actions of ketamine and halothane became antagonistic after treatment with pertussis toxin. 5. The interaction of ketamine and halothane was similar to the interaction of morphine and halothane.

引用

页码：1183 / 1187

页数：5

共 42 条

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