HYPERGLYCEMIA SUPPRESSES THE ADRENAL-MEDULLARY RESPONSE TO HYPOXEMIA

被引:8
作者
COHEN, WR
DEUTSCH, J
机构
[1] Dept. of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY
[2] Albert Einstein College of Medicine, Belfer Educational Center, Bronx, NY 10461
关键词
D O I
10.2337/diabetes.43.5.645
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
An in vivo microdialysis technique was used to study adrenal medullary function in 6 euglycemic and 6 hyperglycemic anesthetized Sprague-Dawley rats exposed to hypoxia. After stabilization of an adrenal dialysis probe, dialyzable adrenal epinephrine and norepinephrine were measured in response to 15 min of 7.8% oxygen breathing in both groups. In euglycemic rats, hypoxia increased epinephrine and norepinephrine by 650 and 320% above baseline, respectively. During hyperglycemia, (mean plasma glucose level 30.0 mM) epinephrine and norepinephrine rose only 119 and 104%, respectively. The catecholamine increase in the hyperglycemic rats was significantly attenuated in comparison to euglycemic controls (epinephrine, P = 0.0232; norepinephrine, P 0.0079). These data demonstrate that acute hyperglycemia has the capacity to suppress the normal adrenal medullary response to hypoxemia.
引用
收藏
页码:645 / 648
页数:4
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