A H-1-NMR STUDY OF THE INTERACTIONS AND CONFORMATIONS OF RATIONALLY DESIGNED BRODIMOPRIM ANALOGS IN COMPLEXES WITH LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE

被引:26
作者
BIRDSALL, B
FEENEY, J
PASCUAL, C
ROBERTS, GCK
KOMPIS, I
THEN, RL
MULLER, K
KROEHN, A
机构
[1] NATL INST MED RES,DIV PHYS BIOCHEM,LONDON NW7 1AA,ENGLAND
[2] F HOFFMANN LA ROCHE & CO LTD,CH-4002 BASEL,SWITZERLAND
[3] ROCHE PROD LTD,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND
关键词
D O I
10.1021/jm00378a025
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1672 / 1676
页数:5
相关论文
共 20 条
[1]   A H-1-NMR STUDY OF THE ROLE OF THE GLUTAMATE MOIETY IN THE BINDING OF METHOTREXATE TO LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE [J].
ANTONJUK, DJ ;
BIRDSALL, B ;
CHEUNG, HTA ;
CLORE, GM ;
FEENEY, J ;
GRONENBORN, A ;
ROBERTS, GCK ;
TRAN, TQ .
BRITISH JOURNAL OF PHARMACOLOGY, 1984, 81 (02) :309-315
[2]   DIHYDROFOLATE-REDUCTASE HYSTERESIS AND ITS EFFECT ON INHIBITOR BINDING ANALYSES [J].
BACCANARI, DP ;
JOYNER, SS .
BIOCHEMISTRY, 1981, 20 (07) :1710-1716
[3]   THE BINDING OF TRIMETHOPRIM TO BACTERIAL DIHYDROFOLATE-REDUCTASE [J].
BAKER, DJ ;
BEDDELL, CR ;
CHAMPNESS, JN ;
GOODFORD, PJ ;
NORRINGTON, FEA ;
SMITH, DR ;
STAMMERS, DK .
FEBS LETTERS, 1981, 126 (01) :49-52
[4]   H-1 NUCLEAR MAGNETIC-RESONANCE STUDIES OF LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE - EFFECTS OF SUBSTRATE AND INHIBITOR BINDING ON HISTIDINE RESIDUES [J].
BIRDSALL, B ;
GRIFFITHS, DV ;
ROBERTS, GCK ;
FEENEY, J ;
BURGEN, A .
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1977, 196 (1124) :251-265
[5]   TRIMETHOPRIM BINDING TO BACTERIAL AND MAMMALIAN DIHYDROFOLATE-REDUCTASE - A COMPARISON BY PROTON AND C-13 NUCLEAR MAGNETIC-RESONANCE [J].
BIRDSALL, B ;
ROBERTS, GCK ;
FEENEY, J ;
DANN, JG ;
BURGEN, ASV .
BIOCHEMISTRY, 1983, 22 (24) :5597-5604
[6]  
BOLIN JT, 1982, J BIOL CHEM, V257, P13650
[7]  
CAYLEY PJ, 1979, BIOCHEMISTRY, V18, P3887
[8]   LARGE-SCALE PURIFICATION AND CHARACTERIZATION OF DIHYDROFOLATE-REDUCTASE FROM A METHOTREXATE-RESISTANT STRAIN OF LACTOBACILLUS-CASEI [J].
DANN, JG ;
OSTLER, G ;
BJUR, RA ;
KING, RW ;
SCUDDER, P ;
TURNER, PC ;
ROBERTS, GCK ;
BURGEN, ASV ;
HARDING, NGL .
BIOCHEMICAL JOURNAL, 1976, 157 (03) :559-571
[9]  
EMSLEY JW, 1966, HIGH RESOLUTION NUCL, V2
[10]  
GRONENBORN A, 1981, BIOCHEMISTRY-US, V20, P1712