3 CONSISTENT PATTERNS OF RESPONSE TO SUBSTITUTED ACRIDINES IN A VARIETY OF BACTERIAL TESTER STRAINS USED FOR MUTAGENICITY TESTING

被引：19

作者：

FERGUSON, LR ^{[1
]}

DENNY, WA ^{[1
]}

MACPHEE, DG ^{[1
]}

机构：

[1] LA TROBE UNIV, DEPT MICROBIOL, BUNDOORA, VIC 3083, AUSTRALIA

来源：

MUTATION RESEARCH | 1985年 / 157卷 / 01期

关键词：

D O I：

10.1016/0165-1218(85)90046-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Substituted acridines (91) were tested for mutagenicity in 1 strain of Escherichia coli (TA78) and 4 strains of Salmonella typhimurium (TA90, TA1537, TA98 and TA100). Compounds fall into 3 groups: (i) inactive in all strains, (ii) active in TA78, TA90 and TA1537, or (iii) active in TA98 and often one or more of the other frameshift strains. Compounds of class iii were previously shown to differ from the others in causing excisible damage to DNA and in showing an enhanced mutagenic response when the plasmid pKM101 is present.

引用

页码：29 / 37

页数：9

共 17 条

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