SOME PHYSICOCHEMICAL PROPERTIES OF GLASSY FELODIPINE

Felodipine, a normally crystalline and very slightly soluble Ca-antagonist was prepared in glassy form and some of its physicochemical properties were determined. The glassy state was confirmed by X-ray diffraction method, scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The influence of the cooling rate of the melt and the heating rate of the glass formed on the glass transition temperature was examined. The jump of the heat capacity, the area under the anomalous endothermic peak and the activation energy of the glass transition were calculated. The influence of the heating rate of the glassy felodipine on its crystallization was studied and the kinetic data of the crystallization were obtained. Dissolution tests were carried out and differences were established.