PROTEIN-KINASE-C IN HUMAN PHEOCHROMOCYTOMA

被引：3

作者：

KODA, Y

UEZONO, Y

KOBAYASHI, H

IZUMI, F

INATOMI, H

YAMADA, Y

OKAMURA, T

机构：

[1] UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT PHARMACOL,1-1 ISEIGAOKA,YAHATANISHI KU,KITAKYUSHU,FUKUOKA 807,JAPAN

[2] UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT UROL,KITAKYUSHU,FUKUOKA 807,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 127卷 / 01期

关键词：

ADRENAL; EXTRAADRENAL; DIFFERENTIATION; HUMAN PHEOCHROMOCYTOMA; PROTEIN KINASE-C; SUBTYPE;

D O I：

10.1016/0304-3940(91)90887-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Subtypes of protein kinase C were analyzed in adrenal and extra-adrenal pheochromocytoma of humans. Almost all protein kinase C of the adrenal tumor was type III, while the enzyme of the extra-adrenal tumor was separated into two major fractions corresponding to type II and type III by hydroxyapatite column chromatography. The extra-adrenal tumor but not the adrenal tumor spontaneously produced neurite-like processes when the cells were cultured in vitro. These results suggest that the high proportion of type II enzyme may reflect neuron-directed differentiation in human pheochromocytoma.

引用

页码：31 / 33

页数：3

共 13 条

[1] CASTAGNA M, 1982, J BIOL CHEM, V257, P7841
[2] HASHIMOTO T, 1988, J NEUROSCI, V8, P1678
[3] ISOZYMIC FORMS OF RAT-BRAIN CA-2+-ACTIVATED AND PHOSPHOLIPID-DEPENDENT PROTEIN-KINASE
HUANG, KP
NAKABAYASHI, H
HUANG, FL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (22) : 8535 - 8539
[4] JUAN D, 1986, ADRENAL GLAND, P383
[5] IDENTIFICATION OF THE STRUCTURES OF MULTIPLE SUBSPECIES OF PROTEIN-KINASE-C EXPRESSED IN RAT-BRAIN
KIKKAWA, U
ONO, Y
OGITA, K
FUJII, T
ASAOKA, Y
SEKIGUCHI, K
KOSAKA, Y
IGARASHI, K
NISHIZUKA, Y
[J]. FEBS LETTERS, 1987, 217 (02) : 227 - 231
[6] KIKKAWA U, 1989, ANN REV BIOCH, V58, P33
[7] PROTEIN KINASE-C SUBTYPES IN TISSUES DERIVED FROM NEURAL CREST
KODA, Y
KOBAYASHI, H
MIZUKI, T
OKAZAKI, M
UEZONO, Y
YANAGIHARA, N
WADA, A
IZUMI, F
[J]. BRAIN RESEARCH, 1990, 518 (1-2) : 334 - 336
[8] THE ROLE OF PROTEIN KINASE-C IN CELL-SURFACE SIGNAL TRANSDUCTION AND TUMOR PROMOTION
NISHIZUKA, Y
[J]. NATURE, 1984, 308 (5961) : 693 - 698
[9] THE MOLECULAR HETEROGENEITY OF PROTEIN KINASE-C AND ITS IMPLICATIONS FOR CELLULAR-REGULATION
NISHIZUKA, Y
[J]. NATURE, 1988, 334 (6184) : 661 - 665
[10] STUDIES AND PERSPECTIVES OF PROTEIN-KINASE-C
NISHIZUKA, Y
[J]. SCIENCE, 1986, 233 (4761) : 305 - 312

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