IMMUNOGENETIC SUSCEPTIBILITY FOR POST-SCHISTOSOMAL HEPATIC-FIBROSIS

被引：15

作者：

HAFEZ, M

HASSAN, SA

ELTAHAN, H

ELSHENNAWY, F

KHASHABA, M

ALTONBARY, Y

ELMORSI, Z

ELSALLAB, S

ELDESOKY, I

ELSHAZLY, A

ETEBA, S

机构：

[1] MANSOURA UNIV, FAC MED, DEPT PATHOL, MANSOURA, EGYPT

[2] MANSOURA UNIV, FAC MED, DEPT PARASITOL, MANSOURA, EGYPT

[3] MANSOURA UNIV, FAC MED, DEPT RADIOL, MANSOURA, EGYPT

[4] MANSOURA UNIV, FAC MED, DEPT PEDIAT, TROP UNIT, MANSOURA, EGYPT

[5] MANSOURA UNIV, FAC MED, DEPT CLIN PATHOL, DIV IMMUNOL, MANSOURA, EGYPT

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1991年 / 44卷 / 04期

关键词：

D O I：

10.4269/ajtmh.1991.44.424

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In 19 children with hepatic fibrosis as the result of continued schistosomiasis mansoni and 20 children without hepatic fibrosis, the following studies were carried out: HLA antigen typing for 30 antigens, immune response of T lymphocytes to schistosome antigen by measuring DNA synthesis evidenced by H-3-thymidine uptake, and measurement of total OKT3+, OKT4+, and OKT8+ cells using monoclonal antibodies. Patients with hepatic fibrosis were mostly high responders in contrast with those without fibrosis. High immune response and susceptibility to post-schistosomal hepatic fibrosis were associated with a high frequency of A2 and B12 antigens and a lack of DR2 antigens, while low response was associated with the presence of the DR2 antigen. The T4+:T8+ ratio showed increased suppressor proportions in patients with low immune response and/or with no hepatic fibrosis. We suggest an immunogenetic susceptibility for post-schistosomal hepatic fibrosis, probably controlled by HLA-linked genes via the suppressor T cells.

引用

页码：424 / 433

页数：10