PERIPHERAL-BLOOD CELL ACTIVITIES OF MONOAMINE OXIDASE-B AND SUPEROXIDE-DISMUTASE IN PARKINSONS-DISEASE

被引:17
作者
CHECKOWAY, H [1 ]
COSTA, LG [1 ]
WOODS, JS [1 ]
CASTOLDI, AF [1 ]
LUND, BO [1 ]
SWANSON, PD [1 ]
机构
[1] UNIV WASHINGTON,SCH MED,DEPT MED,DIV NEUROL,SEATTLE,WA 98195
关键词
PARKINSONS DISEASE; MONOAMINE OXIDASE-B; SUPEROXIDE DISMUTASE; BIOMARKERS;
D O I
10.1007/BF02260077
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Monoamine oxidase type B (MAO-B) and superoxide dismutase (SOD) are two enzyme systems that are potentially relevant to an oxidative stress model of Parkinson's disease (PD) causation. Activities of MAO-B in platelets (nmol/10(8) cells/hr) and total SOD in lymphocytes (Using protein) were assayed among 28 cases of idiopathic PD and 22 controls. As anticipated, MAO-B was lowest in PD cases on selegiline (L-deprenyl) therapy (mean 1.10). There was a slight deficit of MAO-B among male cases not taking selegiline compared to controls (3.78 vs. 4.15), but the opposite trend was observed for females (6.18 vs. 4.16). SOD was slightly higher in cases (7.40), than controls (6.81). Excess SOD among PD cases was seen irrespective of gender, age, or selegiline treatment, although none of the differences was statistically significant. Future research on SOD should take advantage of the availability of assays specific for the cytosolic and mitochondrial forms of the enzyme.
引用
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页码:283 / 290
页数:8
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