ANTAGONISM BY FORSKOLIN OF THE 5-HT3 RECEPTOR-MEDIATED CURRENT IN NODOSE GANGLION NEURONS IS INDEPENDENT OF CYCLIC-AMP

被引:5
作者
FAN, P
机构
[1] Laboratory of Molecular and Cellular Neurobiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852
关键词
NODOSE GANGLION; 5-HT3; RECEPTOR; PATCH-CLAMP; FORSKOLIN; CYCLIC AMP; DESENSITIZATION;
D O I
10.1016/0006-8993(94)90201-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effect of forskolin on the inward current mediated by 5-HT3 receptors (5-HT current) was investigated in rat nodose ganglion neurons. Forskolin inhibited the peak amplitude of the 5-HT current and increased current desensitization in a dose-dependent manner. Dideoxyforskolin, which does not stimulate adenylate cyclase, had a similar inhibitory effect on the 5-HT current. The effect of forskolin was neither mimicked by intracellular application of exogenous cyclic AMP (0.5 to 3 mM) nor occluded by intracellular forskolin (30 mu M) or protein kinase inhibitor H-7 (100 mu M). Intracellular applications of forskolin, cyclic AMP or H-7 had no effect on 5-HT current. Data suggest that forskolin acted at an extracellular site on 5-HT3 receptors and this effect of forskolin was not mediated by cyclic AMP-dependent processes.
引用
收藏
页码:16 / 19
页数:4
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