INHIBITION OF LIPOXYGENASE AND PROSTAGLANDIN ENDOPEROXIDE SYNTHASE BY ANACARDIC ACIDS

被引：73

作者：

GRAZZINI, R

HESK, D

HEININGER, E

HILDENBRANDT, G

REDDY, CC

COXFOSTER, D

MEDFORD, J

CRAIG, R

MUMMA, RO

机构：

[1] PENN STATE UNIV, DEPT ENTOMOL, UNIVERSITY PK, PA 16802 USA

[2] PENN STATE UNIV, INTERDEPT GRAD PROGRAM GENET, UNIVERSITY PK, PA 16802 USA

[3] PENN STATE UNIV, DEPT VET SCI, UNIVERSITY PK, PA 16802 USA

[4] PENN STATE UNIV, DEPT BIOL, UNIVERSITY PK, PA 16802 USA

[5] PENN STATE UNIV, DEPT HORT, UNIVERSITY PK, PA 16802 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 176卷 / 02期

关键词：

D O I：

10.1016/S0006-291X(05)80252-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

C22:1 ω5-anacardic acid was found to be a good inhibitor of both potato lipoxygenase and ovine prostaglandin endoperoxide synthase with approximate IC50's of 6 and 27 μM, respectively. Very similar inhibition was seen with the crude exudate, rich in ω5-anacardic acids, from glandular trichomes of an arthropod-resistant strain of geranium, Pelargonium xhortorum. The saturated anacardic acid (C22:0 sat), abundant in the trichome exudate of susceptible strains, was nearly as inhibitory toward both prostaglandin endoperoxide synthase and lipoxygenase as the ω5-unsaturated compound. However, the dimethyl derivative of C22:1 ω5-anacardic acid was a poor inhibitor of prostaglandin endoperoxide synthase and caused only moderate (32%) inhibition of lipoxygenase even at 135 μM. The possible role of prostaglandin endoperoxide synthase and lipoxygenase inhibition in the enhanced pest resistance of geraniums which produce the ω5-AnAs is discussed. © 1991 Academic Press, Inc.

引用

页码：775 / 780

页数：6