DISCOVERY AND STRUCTURE-ACTIVITY RELATIONSHIP OF A SERIES OF 1-CARBA-1-DETHIACEPHEMS EXHIBITING ACTIVITY AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS

被引：29

作者：

TERNANSKY, RJ ^{[1
]}

DRAHEIM, SE ^{[1
]}

PIKE, AJ ^{[1
]}

BELL, FW ^{[1
]}

WEST, SJ ^{[1
]}

JORDAN, CL ^{[1
]}

WU, CYE ^{[1
]}

PRESTON, DA ^{[1
]}

ALBORN, W ^{[1
]}

KASHER, JS ^{[1
]}

HAWKINS, BL ^{[1
]}

机构：

[1] ELI LILLY & CO,LILLY CORP CTR,LILLY RES LABS,INDIANAPOLIS,IN 46285

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 36卷 / 14期

关键词：

D O I：

10.1021/jm00066a006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and antimicrobial activity of several new 1-carba-1-dethiacephalosporins is described. The discovery of unique activity of some of the analogues against methicillin-resistant Staphylococcus aureus led to the development of a structure-activity relationship designed to optimize this activity. The results of this investigation along with the pharmacokinetic select compounds are described.

引用

页码：1971 / 1976

页数：6