A NEW APPLICATION FOR LIPOSOMES IN CANCER-THERAPY - IMMUNOLIPOSOMES BEARING ENZYMES (IMMUNO-ENZYMOSOMES) FOR SITE-SPECIFIC ACTIVATION OF PRODRUGS

被引：41

作者：

VINGERHOEDS, MH ^{[1
]}

HAISMA, HJ ^{[1
]}

VANMUIJEN, M ^{[1
]}

VANDERIJT, RBJ ^{[1
]}

CROMMELIN, DJA ^{[1
]}

STORM, G ^{[1
]}

机构：

[1] FREE UNIV AMSTERDAM HOSP,DEPT MED ONCOL,AMSTERDAM,NETHERLANDS

来源：

FEBS LETTERS | 1993年 / 336卷 / 03期

关键词：

MONOCLONAL ANTIBODY; LIPOSOME; ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY; ADEPT; TARGETED DRUG DELIVERY;

D O I：

10.1016/0014-5793(93)80861-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have tested a new type of immunoliposomes which may effectively mediate the targeting of enzymes to be used for site-specific prodrug activation (immuno-enzymosomes). The enzyme beta-glucuronidase, capable of activating the prodrug epirubicin-glucuronide (epi-glu), was coupled to the external surface of immunoliposomes directed towards ovarian cancer cells. A significant increase in cytotoxicity of the prodrug epi-glu was shown when the in vitro cultured cancer cells were pretreated with these immuno-enzymosomes.

引用

页码：485 / 490

页数：6

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