PREDICTING THE CYTOCHROME-P450 MEDIATED METABOLISM OF XENOBIOTICS

被引：119

作者：

KORZEKWA, KR ^{[1
]}

JONES, JP ^{[1
]}

机构：

[1] UNIV ROCHESTER, SCH MED, DEPT PHARMACOL, ROCHESTER, NY 14642 USA

来源：

PHARMACOGENETICS | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1097/00008571-199302000-00001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The cytochrome P450s play a unique role in the metabolism of xenobiotics. Characteristics which allow a vast number of foreign compounds to be metabolized by a limited number of enzymes include broad substrate specificity and broad regioselectivity. Because of their importance in both the metabolism and toxicity of drugs and environmental contaminants, efforts are being made to use computational methods to predict these biotransformation pathways. This review describes the recent progress towards the prediction of the tertiary structures of the various P450s and the determination of the electronic characteristics ot' substrates which determine their tendency to be oxidized by the P450s.

引用

页码：1 / 18

页数：18

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