MICRON-SCALE PATTERNING OF BIOLOGICAL MOLECULES

被引：108

作者：

PRITCHARD, DJ ^{[1
]}

MORGAN, H ^{[1
]}

COOPER, JM ^{[1
]}

机构：

[1] UNIV GLASGOW,DEPT ELECTR & ELECT ENGN,GLASGOW G12 8LT,LANARK,SCOTLAND

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 01期

关键词：

ANTIBODIES; IMMOBILIZATION; IMMUNOSENSORS; PHOTOLITHOGRAPHY;

D O I：

10.1002/anie.199500911

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Site‐specific attachment of biological molecules on gold and silicon dioxide surfaces has been achieved: The surface is modified with the receptor/ligand pair avidin D/photobiotin 1 and exposed to light through a mask in the presence of a protein solution; binding only occurs in the exposed areas. After unbound material is removed by washing, this process can be repeated several times to produce a two‐dimensional pattern. One of the potential applications of this technique is the patterning of antibodies in a format that can be used in a multi‐analyte immunosensor. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：91 / 93

页数：3

共 10 条

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