EFFECTS OF LONG-TERM ADMINISTRATION OF ACETAMINOPHEN ON THE NUTRITIONAL UTILIZATION OF DIETARY-PROTEIN

被引：6

作者：

VARELAMOREIRAS, G ^{[1
]}

RUIZROSO, B ^{[1
]}

VARELA, G ^{[1
]}

机构：

[1] UNIV COMPLUTENSE MADRID, FAC FARM, DEPT NUTR, MADRID 3, SPAIN

来源：

ANNALS OF NUTRITION AND METABOLISM | 1991年 / 35卷 / 05期

关键词：

ACETAMINOPHEN; DRUG-NUTRIENT INTERACTIONS; DIETARY PROTEIN; XENOBIOTICS; PROTEIN DEFICIENCY;

D O I：

10.1159/000177661

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of long-term administration of acetaminophen to rats on the dietary protein utilization was investigated using protein-sufficient and protein-deficient diets. Fat digestibility, food efficiency and some hepatic parameters were also determined. Results showed that there was a significant decrease in the nitrogen metabolic utilization in the protein-sufficient treated animals compared to the untreated group (0.59 +/- 0.03 vs. 0.75 +/-0.03, p < 0.001). The protein-deficient diet and the administration of the drug resulted in lower nitrogen metabolic utilization in either of the two metabolic balances (days 4-11 and 36-42). These changes were not accompanied by variations in the nitrogen digestibility coefficient.

引用

页码：303 / 308

页数：6