SYNTHESIS OF SPHINGANINE ANALOGS MODIFIED IN THE HEAD GROUP

被引：22

作者：

KOLTER, T

VANECHTENDECKERT, G

SANDHOFF, K

机构：

[1] Institut für Organische Chemie, Biochemie der Universität Bonn, D-53121 Bonn

来源：

TETRAHEDRON | 1994年 / 50卷 / 47期

关键词：

D O I：

10.1016/S0040-4020(01)89349-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of sphinganine analogues modified in the head group is reported. The target compounds are efficiently prepared by means of the Henry reaction. Synthesis and results of preliminary investigations of the derivatives as potential inhibitors of sphingolipid biosynthesis are presented.

引用

页码：13425 / 13432

页数：8

共 55 条

[1]

ANTES P, 1992, EUR J CELL BIOL, V59, P27

[2]

BAR T, 1993, LIEBIGS ANN CHEM, P419

[3]

BIRK R, 1993, LIEBIGS ANN CHEM, P71

[4] SYNTHESIS OF POTENTIAL INHIBITORS OF THE GLYCOSPHINGOLIPID BIOSYNTHESIS [J].