HPLC DETERMINATION OF BECLOMETHASONE DIPROPIONATE AND ITS DEGRADATION PRODUCTS IN BULK DRUG AND PHARMACEUTICAL FORMULATIONS

被引：6

作者：

DEORSI, D

GAGLIARDI, L

CHIMENTI, F

TONELLI, D

机构：

[1] IST SUPER SANITA,I-00161 ROME,ITALY

[2] UNIV REGGIO CALABRIA,FAC FARM,I-89100 REGGIO CALABRIA,ITALY

[3] UNIV BOLOGNA,DIPARTIMENTO CHIM IND & MAT,I-40136 BOLOGNA,ITALY

来源：

ANALYTICAL LETTERS | 1995年 / 28卷 / 09期

关键词：

BECLOMETHASONE DIPROPIONATE; BECLOMETHASONE MONOPROPIONATES; BECLOMETHASONE ALCOHOL; HPLC; ANALYSIS IN BULK DRUG AND PHARMACEUTICALS;

D O I：

10.1080/00032719508002772

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An HPLC method for the simultaneous determination of beclomethasone dipropionate and its principal degradation products has been developed. The only sample treatment necessary for the analysis is its dilution with methanol. The practical detection limit is 0.02 % of each impurities in terms of the parent drug, whereas the absolute limit of detection is 2.5 ng of each injected compound. The method has been applied to the analysis of both pharmaceutical formulations and samples of bulk drug.

引用

页码：1655 / 1663

页数：9

共 7 条

[1] A RAPID AND HIGHLY SENSITIVE METHOD FOR THE QUANTITATIVE-DETERMINATION OF DEXAMETHASONE IN PLASMA, SYNOVIAL-FLUID AND TISSUES BY COMBINED GAS-CHROMATOGRAPHY NEGATIVE-ION CHEMICAL IONIZATION MASS-SPECTROMETRY [J].

GIRAULT, J ;

ISTIN, B ;

FOURTILLAN, JB .

BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, 1990, 19 (05) :295-302

[2]

JENNER WN, 1988, METODOL SURV BIOCH A, V18, P77

[3]

MULLHOLLAND M, 1985, ANAL P, V22, P140

[4]

SANGHAVI NM, 1993, INDIAN DRUGS, V30, P129

[5]

TOKUNAGA H, 1984, CHEM PHARM BULL, V32, P4012

[6] DEVELOPMENT OF A HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHIC METHOD FOR THE MULTI-SCREENING ANALYSIS OF CORTICOSTEROIDS [J].

VANOOSTHUYZE, KE ;

VANPOUCKE, LSG ;

DELOOF, ACA ;

VANPETEGHEM, CH .

ANALYTICA CHIMICA ACTA, 1993, 275 (1-2) :177-182

[7]

1993, BRIT PHARMACOPOEIA, V1, P63

← 1 →