TUMOR SUPPRESSION IN DROSOPHILA IS CAUSALLY RELATED TO THE FUNCTION OF THE LETHAL(2)TUMOROUS IMAGINAL DISKS GENE, A DNAJ HOMOLOG

被引：66

作者：

KURZIKDUMKE, U ^{[1
]}

GUNDACKER, D ^{[1
]}

RENTROP, M ^{[1
]}

GATEFF, E ^{[1
]}

机构：

[1] UNIV MAINZ, INST GENET, D-55099 MAINZ, GERMANY

来源：

DEVELOPMENTAL GENETICS | 1995年 / 16卷 / 01期

关键词：

TUMOR SUPPRESSION; DROSOPHILA; IMAGINAL DISKS; DNAJ-HOMOLOG; CHAPERONE;

D O I：

10.1002/dvg.1020160110

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Drosophila melanogaster tumor suppressor gene lethal(2)tumorous imaginal discs (l(2)tid) causes in homozygotes malignant growth of cells of the imaginal discs and the death of the mutant larvae at the time of puparium formation. We describe the molecular cloning of the l(2)tid(+) gene and its temporal expression pattern in the wild-type and mutant alleles. Germ line rescue of the tumor phenotype was achieved with a 7.0 kb HindIII-fragment derived from the polytene chromosome band 59F5. The l(2)tid(+) gene spans approximately 2.5 kb of genomic DNA. The protein coding region, 1,696 bps long, is divided by an intron into two exons. The predicted Tid(56) protein contains 518 amino acids and possesses a theoretical molecular weight of 56 kDa. It shows significant homology to all known DnaJ related proteins from bacteria, yeast, and man. The possible function of the Tid(56) protein in tumor suppression is delineated. (C) 1995 Wiley-Liss, Inc.

引用

页码：64 / 76

页数：13

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