INDUCTION OF CELL-ASSOCIATED INTERLEUKIN-1 THROUGH STIMULATION OF THE ADHESION-PROMOTING PROTEINS LFA-1 (CD11A/CD18) AND CR3 (CD11B/CD18) OF HUMAN MONOCYTES

被引：57

作者：

COUTURIER, C ^{[1
]}

HAEFFNERCAVAILLON, N ^{[1
]}

WEISS, L ^{[1
]}

FISCHER, E ^{[1
]}

KAZATCHKINE, MD ^{[1
]}

机构：

[1] HOP BROUSSAIS,INSERM,U28,UNITE IMMUNOPATHOL,96 RUE DIDOT,F-75674 PARIS 14,FRANCE

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 05期

关键词：

D O I：

10.1002/eji.1830200508

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Serum‐free culture of human monocytes in the presence of monoclonal antibodies to the LFA‐1 α chain (CD11a), CR3 α chain (CD11b) or β chain (CD18) bound to Sepharose induced the dose‐dependent production of cell‐associated interleukin (IL) 1 activity and of IL 1α and IL 1β antigens, but no release of extracellular IL 1 activity or antigen in the culture medium. Triggering of IL 1 production was also observed with insolubilized anti‐CD11/CD18 F(ab')2 antibodies. Two cross‐linked antibodies recognizing distinct epitopes on the CD11b molecule induced cell‐associated IL 1. Soluble antibodies did not induce IL 1 production. The kinetics of induction of IL 1 by stimulation of adhesion‐promoting proteins differed from those of IL 1 induction by adhesion to plastic. The lack of induction of IL 1 release by stimulation of the CD11/CD18 molecules resembled the intracellular accumulation of IL 1 induced by lipid A. Induction of IL 1 by adhesive processes may be a mechanism by which T cells trigger IL 1 production by monocytes during antigen presentation. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：999 / 1005

页数：7

共 55 条

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