CHROMOSOME ANALYSIS IN THE MANAGEMENT OF PATIENTS WITH NON-HODGKINS-LYMPHOMA

被引：20

作者：

OFFIT, K

机构：

[1] Departments of Medicine (Lymphoma Service) and Pathology (Cytogenetics Service), Memorial Hospital, Memorial Sloan Kettering Cancer Center, NY

来源：

LEUKEMIA & LYMPHOMA | 1992年 / 7卷 / 04期

关键词：

CYTOGENETICS; MOLECULAR DIAGNOSTICS; CHROMOSOME TRANSLOCATIONS; NON-HODGKINS LYMPHOMA; PROGNOSIS; THERAPY;

D O I：

10.3109/10428199209049778

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Analysis of chromosome abnormalities in non-Hodgkin's lymphoma has stimulated a basic inquiry into the mechanisms of gene deregulation in human tumors. A growing literature has also correlated cytogenetic and molecular genetic features of lymphoma with patient prognosis and other clinical features of the disease. The goal of this report is to review those genetic abnormalities which are currently useful in the clinical management of patients with lymphoma, and to provide a conceptual framework for this growing literature.

引用

页码：275 / 282

页数：8

共 83 条

[31]

Offit K., Richardson M., Chen Q., Et al., Nonrandom chromosomal aberrations are associated with sites of tissue involvement in non-Hodgkin's lymphoma, Cancer Genetics and Cytogenetics, 37, pp. 85-93, (1989)

[32]

Juneja S., Lukeis R., Tan L., Et al., Cytogenetic analysis of 147 cases of non-Hodgkin's lymphoma: non-random chromosomal abnormalities and histologic correlations, British Journal of Haematology, 76, pp. 231-237, (1990)

[33]

Schouten H.C., Sanger W., Weisenburger D.D., Et al., Chromosomal abnormalities in untreated patients with non-Hodgkin's lymphoma: associations with histology, clinical characteristics, and treatment outcome, Blood, 75, pp. 1841-1847, (1990)

[34]

Schouten H.C., Sanger W., Weisenburger D.D., Et al., Abnormalities involving chromosome 6 in newly diagnosed patients with non-Hodgkin's lymphoma, Cancer Genetics and Cytogenetics, 47, pp. 73-82, (1990)

[35]

Offit K., Wong G., Filippa D.A., Et al., Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: clinical correlations, Blood, 11, pp. 1508-1515, (1991)

[36]

Offit K., Jhanwar, Ladanyi S.C., Et al., Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: correlations between recurrent aberrations, histology, and exposure to cytotoxic treatment, Genes, Chromosomes, and Cancer, 3, pp. 189-201, (1991)

[37]

Offit K., Parsa K., Jhanwar S.C., Filippa D.A., Chaganti R.S.K., (9

[38]

14)(p13

[39]

q32) denotes a subset of low to intermediate grade B cell non-Hodgkin's lymphoma., (1991)

[40]

Correlation of chromosome abnormalities with histologic and immunologic characteristics in non-Hodgkin's lymphoma and adult T cell leukemia-lymphoma, Blood, 70, pp. 1554-1564, (1987)

← 1 2 3 4 5 6 7 8 9 →