A SHORT ROUTE TO AVENACIOLIDE AND ISOAVENACIOLIDE VIA RADICAL CYCLIZATION

被引：14

作者：

BURKE, SD

JUNG, KW

PERRI, RE

机构：

[1] Department of Chemistry, University of Wisconsin-Madison, Madison

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 32期

基金：

美国国家卫生研究院;

关键词：

AVENACIOLIDE; ISOAVENACIOLIDE; RADICAL CYCLIZATION; PUMMERER REARRANGEMENT;

D O I：

10.1016/S0040-4039(00)78198-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The bicyclic ether/lactone 5 was prepared from 7 in 6 steps including radical cyclization and a Pummerer rearrangement. After 5 was converted to 12 and 13 under KecK's conditions, divergent formal total syntheses of avenaciolide and isoavenaciolide were accomplished in four additional steps.

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页码：5841 / 5844

页数：4

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