UV, stress and aging

被引：158

作者：

Debacq-Chainiaux, Florence ^{[1
]}

Leduc, Cedric ^{[1
]}

Verbeke, Alix ^{[1
]}

Toussaint, Olivier ^{[1
]}

机构：

[1] Univ Namur FUNDP, NARILIS, Res Unit Cellular Biol URBC, Namur, Belgium

来源：

DERMATO-ENDOCRINOLOGY | 2012年 / 4卷 / 03期

关键词：

UVB; fibroblasts; keratinocytes; senescence;

D O I：

10.4161/derm.23652

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 [皮肤病与性病学];

摘要：

Skin is a model of choice in studies on aging. Indeed, skin aging can be modulated by internal and external factors, reflecting its complexity. Two types of skin aging have been identified: intrinsic, mainly genetically determined and extrinsic-also called "photo-aging"-resulting on the impact of environmental stress and more precisely of UV rays. Simplified in vitro models, based on cellular senescence, have been developed to study the relationship between UV and aging. These models vary on the cell type (fibroblasts or keratinocytes, normal or immortalized) and the type of UV used (UVA or UVB).

引用

页码：236 / 240

页数：5

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