MOLECULAR-BIOLOGY IN THE DIAGNOSIS AND EPIDEMIOLOGY OF TUBERCULOSIS

被引:20
作者
DROBNIEWSKI, FA
KENT, RJ
STOKER, NG
UTTLEY, AHC
机构
[1] DULWICH HOSP,KINGS COLL SCH MED & DENT,DEPT MED MICROBIOL,LONDON SE22 8QF,ENGLAND
[2] UNIV LONDON LONDON SCH HYG & TROP MED,DEPT CLIN SCI,BACTERIAL MOLEC GENET UNIT,LONDON WC1E 7HT,ENGLAND
基金
英国惠康基金;
关键词
TUBERCULOSIS; RECOMBINANT DNA; MYCOBACTERIUM-TUBERCULOSIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; DNA FINGERPRINTING; POLYMERASE CHAIN REACTION; PULSED-FIELD GEL ELECTROPHORESIS; MULTIPLE DRUG RESISTANCE;
D O I
10.1016/0195-6701(94)90089-2
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Tuberculosis is the predominant infectious cause of mortality today, killing 3 million people annually. The cornerstones of diagnosis test on microscopy of specimens using auramine and Ziehl-Neelsen stains followed by culture on Lowenstein-Jensen or alternative media. The long generation time of Mycobacterium tuberculosis means 2-8 weeks usually elapse before a result is available to the clinician. This has stimulated research into the use of molecular diagnostic techniques. This article reviews the use and limitations of DNA hybridization, restriction fragment length polymorphism, pulsed-field gel electrophoresis and the polymerase chain reaction in the diagnosis and epidemiology of tuberculosis. The applicability of molecular biology to determine drug resistance is also addressed.
引用
收藏
页码:249 / 263
页数:15
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