LEVEL OF EXPRESSION OF E-CADHERIN MESSENGER-RNA IN COLORECTAL-CANCER CORRELATES WITH CLINICAL OUTCOME

被引：110

作者：

DORUDI, S

HANBY, AM

POULSOM, R

NORTHOVER, J

HART, IR

机构：

[1] ST THOMAS HOSP,RICHARD DIMBLEBY ICRF LAB,LONDON SE1 7EH,ENGLAND

[2] ST MARKS HOSP,IMPERIAL CANC RES FUND,COLORECTAL CANC UNIT,LONDON EC1V 2PS,ENGLAND

[3] IMPERIAL CANC RES FUND,HISTOPATHOL UNIT,LONDON WC2A 3PX,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1995年 / 71卷 / 03期

关键词：

COLORECTAL CARCINOMAS; E-CADHERIN; PROGNOSIS;

D O I：

10.1038/bjc.1995.119

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A series of colorectal carcinomas (n = 49) resected from patients with known clinical outcomes were analysed for E-cadherin expression using in situ hybridisation to measure mRNA. Patients surviving 5 years or longer (n = 31) exhibited significantly higher levels of E-cadherin mRNA than those surviving less than 5 years (n = 18, P = 0.003). These preliminary results from this small sample suggest that E-cadherin expression may be a useful prognostic marker in colorectal cancer patients.

引用

页码：614 / 616

页数：3

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