EFFECTS OF DIETARY-SODIUM AND FISH OIL ON BLOOD-PRESSURE DEVELOPMENT IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS

被引：22

作者：

HOWE, PRC ^{[1
]}

LUNGERSHAUSEN, YK ^{[1
]}

ROGERS, PF ^{[1
]}

GERKENS, JF ^{[1
]}

HEAD, RJ ^{[1
]}

SMITH, RM ^{[1
]}

机构：

[1] UNIV NEWCASTLE,DISCIPLINE CLIN PHARMACOL,NEWCASTLE,NSW 2308,AUSTRALIA

来源：

JOURNAL OF HYPERTENSION | 1991年 / 9卷 / 07期

关键词：

FISH OIL; DIETARY SODIUM; EICOSAPENTAENOIC ACID; BLOOD PRESSURE; VASOCONSTRICTION; HYPERTENSIVE RATS; SYMPATHETIC NERVE ACTIVITY;

D O I：

10.1097/00004872-199107000-00009

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The postulated antihypertensive effect of dietary fish oil and the influence of dietary sodium on this effect were evaluated in young stroke-prone spontaneously hypertensive rats (SHRSP) by direct intra-arterial measurement of blood pressure. Weaning rats were fed synthetic diets containing olive oil or eicosapentaenoic acid-enriched fish oil (5% of dry weight) with normal (0.23%) or high (2.8%) sodium content. Catheters were implanted after 3 months for blood pressure measurement under resting conditions and to sample blood or catecholamine determinations. Effects of fish oil on vascular reactivity were assessed in the in situ blood-perfused mesentery. The overall observation, from a series of experiments, was that feeding diets containing 5% fish oil to young SHRSP resulted in a small but consistent suppression of the development of hypertension. This effect could be counteracted, however, by increasing dietary sodium intake. Observations after ganglion blockade indicate that the antihypertensive effect of fish oil is unlikely to result from a reduction in sympathetic vascular tone.

引用

页码：639 / 644

页数：6